Friday, 30 June 2017

Drug maker MSD hit by ransomware, Indian website down

“We believe we have contained the problem and are working on recovery plans with our external IT partners,” MSD said in its latest update.

US drug maker Merck, known as MSD outside the United States and Canada, the maker of top-selling diabetic drug Januvia and cervical cancer vaccine Gardasil, among others, said its computer network was compromised on June 27 as part of a global cyber-attack.

The website of MSD India was still down at the time of filing the story, while its global website is up and running.

We believe we have contained the problem and are working on recovery plans with our external IT partners,” MSD said in its latest update.

We also are cooperating with global cyber security agencies given the scope of the attack,” the statement added.

MSD said as it is addressing the potential impact to its business, while it continues to work on minimizing disruption to patients, customers and its other business partners.

The global pharma major said it it immediately shut down its IT systems as a precautionary measure to help contain the problem and, where needed, moved to business continuity plans to ensure ongoing operations.

To meet patient and customer needs, we are working to maintain a sufficient supply of medicines and vaccines,” MSD said.

MSD was hit by a ransomware that infects and locks a computer system, and then demands a USD 300 ransom to be paid in bitcoins.

Many firms, including Symantec, have suggested the ransomware is a variant of Petya, a known ransomware. But according to security firm Kaspersky Lab, preliminary findings indicate the attacks are from a new ransomware that it's now calling "ExPetr." The attackers were using a Windows operating system flaw called EternalBlue to spread through corporate networks.

MSD with sales of around USD 40 billion in 2016 is one of the world’s biggest drug makers.

To be sure – the hackers didn’t limit their attacks on MSD alone; They have penetrated the networks of several big corporates including British advertising agency WPP, Russian oil and gas giant Rosneft, global logistics company FedEx and Danish shipping firm Maersk, among others.

Wednesday, 28 June 2017

Desh Bandhu Gupta: The humble professor

I have never looked at numbers. Numbers are just an outcome of the work done,” Desh Bandhu Gupta, the founder chairman of pharmaceutical company Lupin, had told Forbes India during an interaction in October 2016. The self-made billionaire passed away in Mumbai on June 26 at the age of 79.

Gupta’s professional life is a testament to what a hardworking, first generation entrepreneur can achieve, and benefit society in the process. The legacy that Gupta, fondly known as DBG, has left behind is the world’s fourth largest generics pharma company by market value and sixth largest in terms of sales, which earned $2.55 billion in revenue in FY17.

To think that Gupta, who was born in Rajgarh, Rajasthan, founded Lupin in 1968 with Rs 5,000 that he borrowed from his wife, shows the long and successful journey he traversed from being a professor of chemistry at the Birla Insitute of Technology and Science, Pilani, to becoming India’s 20th richest person with an estimated net worth of $5.1 billion (according to the 2016 Forbes India Rich List).  

Gupta’s philosophy towards business is best exemplified by the rationale with which he named his company Lupin. The name draws reference from the Lupinus flower, which is known to nourish the soil in which it grows. With a disarming smile, humility and knowledge of chemistry (he holds an MSc degree in chemistry) as his biggest assets, Gupta founded Lupin as a manufacturer of vitamins, but the desire to serve a larger, social cause saw Lupin transition into manufacturing drugs to combat tuberculosis (TB), an infectious airborne disease that has claimed millions of lives in India over the years. Lupin persisted with the manufacture of anti-TB drugs for the domestic market despite the fact that it was a low-margin business, with drug prices largely controlled by the government.

In fact, Gupta was a contrarian in the sense that he believed that the prices of certain essential drugs needed to be controlled by the government, says Habil Khorakiwala, chairman of Wockhardt, who knew Gupta for four decades and called him a “competitor and a friend”.

In the late 80s and early 90s, Khorakiwala and Gupta were part of a committee formed to deliberate on drug policy, which comprised industry leaders such as themselves and bureaucrats. “We had a different perspective of the industry. His (Gupta’s) view was that some amount of price control was required, whereas my belief was that there is enough competition in the industry to let prices find their own level,” Khorakiwala recalls.

While the focus on manufacturing drugs that were of relevance to India continued on one hand, Lupin also expanded into new therapeutic areas, including complex generics and specialty drugs across cardiovascular, diabetology, asthma, paediatrics and gastrointestinal-related disorders, among others, and global regions like the US, Europe, Latin America and Japan.

DBG’s concern for social issues wasn’t restricted to making anti-TB drugs alone. Much before it became mandatory for Indian companies to spend a portion of their earnings towards corporate social responsibility measures, Gupta had pioneered the foundation of the Lupin Human Welfare and Research Foundation in 1988. Through the foundation, Lupin works across 3,463 villages across India for their economic, social and infrastructure development, impacting 2.8 million families. 

It isn’t as if Gupta didn’t make mistakes and some of the calls he took didn’t work out as planned. But while it isn’t uncommon for entrepreneurs to err at times, it is the determination with which they bounce back that distinguishes them. In Lupin’s case, an unrelated diversification into real estate in the 1990s didn’t augur well for the company and left it saddled with a mountain of debt. The singular focus on India also meant that peers like Cipla and Ranbaxy made headway in the foreign markets.

To pare debt, Gupta sold a portion of his stake in Lupin to CVC International, a Citigroup company in 2003 and the new investors wanted a managing director to be brought from outside to bring the company back on track. While the induction of an external professional for the top job at Lupin may have been at the behest of investors, the freedom that Gupta granted to Kamal K Sharma to steer the ship saw the foundation of Lupin’s future growth, and a deep bond of friendship, being laid.

What followed was a twin process of balance sheet repair – aided by strict control on costs – and focus on research and development, which aided Lupin’s successful entry into developed markets like Japan and the US.

Sharma hung up his boots as Lupin’s MD after a decade in 2013, and made way for Gupta’s children – Vinita Gupta and Nilesh Gupta – to assume responsibilities as chief executive officer and MD respectively. He, however, continues as the company’s vice chairman and commands the same respect as Vinita and Nilesh.

While Vinita and Nilesh took the company on an aggressive and inorganic path of growth, Gupta and Sharma continued to be the sounding board for all major decisions, especially those related to mergers and acquisitions. “He (Gupta) ensured a great combination of professional leadership and entrepreneurial spirit and risk-taking ability in the organisation,” Khorakiwala said, and added that it was due to entrepreneurs like Gupta that the Indian pharmaceutical sector had become a globally competitive force to reckon with.

With his passing away, India and the pharmaceutical industry has lost one of its tallest leaders,” Khorakiwala summed up.  

Dragons's Den_Competition for researchers

1. Dragons' Den:
Dragons's Den is a competition whose purpose is to encourage young researchers to move forward in their fields of interest. The winners receive a substantial prize to support their future research work. 

2. Eligibility:
This contest is open to students and researchers with maximum age of 35 and no permanent academic position. The proposer must be properly registered with IUCr 2017 (24th Congress & General Assembly of the International Union of Crystallography 2017 from 21 – 28 August 2017) – i.e. he she must have an Access Key, and all registration fees paid. 

3. Submitting a Proposal:
Eligible researchers must submit a proposal by filling an online form. The proposal must be for future research work and not for research work already undertaken or ongoing or presented at the IUCr 2017 Congress. Details of the Proposer and the Project Proposed will be required by the form. 

4. Submission Deadline:
15 July 2017. 

5. Judging Proposals:
Applications will be shortlisted by a judging panel nominated by the IUCr2017 LOC. 

6. Inside the Dragons' Den:
Authors of selected proposals will present and defend their proposal in front of the Dragons (a Commission of 5 expert crystallographers). Each presenter will be given a maximum of 5 minutes to convince the Dragons about their idea and to answer their fiery questions. Decision on what projects are funded is taken immediately at the end of all presentations. Please bring any age proof document with you. 

7. The Prize:
Awardees receive a grant of INR 1,50,000 or approximately US$2300. Awards are sponsored by: IUCr2017; STOE; Springer; Elsevier.


Welcome back to Pharma Literati blog after the vacation in India

As all the bloggers were on summer vacation, the posts were scarce and the activities were rare. We welcome back all our readers to the blog as we look ahead for exciting times for the pharma academia, industries and all the stakeholders. 

We are also starting the second leg of Pharma Innovation Yatra soon.

Also, there are lots of newer activities planned by the bloggers and the brains behind the blog.

Happy reading.

Team Pharma Literati...