Antibiotics discovered that kill bacteria in a new way.
The newly-found corbomycin and the lesser-known complestatin have a never-before-seen way to kill bacteria, which is achieved by blocking the function of the bacterial cell wall. The discovery comes from a family of antibiotics called glycopeptides that are produced by soil bacteria. The researchers also demonstrated in mice that these new antibiotics can block infections caused by the drug resistant Staphylococcus aureus which is a group of bacteria that can cause many serious infections. The findings were published in Nature . " Bacteria have a wall around the outside of their cells that gives them shape and is a source of strength ," said study first author Beth Culp, a PhD candidate in biochemistry and biomedical sciences at McMaster. "Antibiotics like penicillin kill bacteria by preventing building of the wall, but the antibiotics that we found actually work by doing the opposite -- they prevent the wall from being broken down. This is critical for...