PHARMA LITERATI

Drug Name K-134 Structure   Drug Code K-134 Synonym OPC-33509 1-cyclopropyl-1-(2-hydroxycyclohexyl)-3-[3-[(2-oxo-1H-quinolin-6-yl)oxy]propyl]urea Molecular Formula C 22 H 29 N 3 O 4 Innovator D. Western Therapeutics Institute Kowa Company, Ltd. Condition Arteriosclerosis obliterans Mechanism of Action Type 3 cyclic nucleotide phosphodiesterase inhibitors (PDE3 inhibitor) Clinical Phase IIb in US

Drug Name Vernakalant Structure   Drug Code RSD1235 Synonym Kynapid, Brinavess (3R)-1-{(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy] cyclohexyl}pyrrolidin-3-ol Molecular Formula C 20 H 31 NO 4 Innovator Cardiome Pharma Corp Merck Condition Prevention of post-operative atrial fibrillation in patients undergoing coronary artery bypass graft surgery. Mechanism of Action Blocks atrial potassium and sodium channels Clinical Phase Not yet approved. (Filed for Orphan Drug Designation) Approved in Europe.

Drug Name Etripamil Structure   Drug Code MSP-2017 Synonym methyl 3-(2-{[(4S)-4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl](methyl)amino}ethyl)benzoate Molecular Formula C 27 H 36 N 2 O 4 Innovator Milestone Pharmaceuticals Condition Acute episodes of paroxysmal supraventricular tachycardia Mechanism of Action Calcium channel antagonist (Intranasal) Clinical Phase II in USA

Drug Name Eleclazine Structure   Drug Code GS-6615 Synonym 4-(pyrimidin-2-ylmethyl)-7-[4-(trifluoromethoxy) phenyl]-2,3-dihydro-1,4-benzoxazepin-5-one Molecular Formula C 21 H 16 F 3 N 3 O 3 Innovator Gilead Sciences Condition Cardiomyopathy Mechanism of Action Sodium channel antagonists Clinical Phase III in USA

Let’s continue our series of Future of Drugs. We are now going to take you through the new drugs that are being developed and those that might actually get approved against the rising incidence of Heart Diseases and Stroke. Ciraparantag has tremendous potential of competing with anticoagulants like edoxaban, rivaroxaban, dabigatran and apixaban. Ciraparantag is to be administered IV.  Drug Name Ciraparantag Structure   Drug Code PER 977 Synonym Aripazine N,N'-(1,4-piperazinediyldi-3,1-propanediyl)bis[2-amino-5-[(aminoiminomethyl)amino]-, (2S,2'S)-pentanamide Molecular Formula C 22 H 48 N 12 O 2 Innovator Perosphere Condition Anticoagulant Reversal Mechanism of Action Blood coagulation factor modulators; Factor Xa inhibitors Clinical Phase II in USA (Fast Track Designation)   ...